He and Dylan had their acting debuts in a commercial for diapers when they were eight months old.
From 2006 to 2008, he and his brother ran a Sprouse Bros brand that included clothes and a book series.
He and Dylan were born to American parents Matthew Sprouse and Melanie Wright in Arezzo, Italy. In 2017, he began a relationship with his Riverdale co-star Lili Reinhart, but the two split in 2020. He has since been romantically linked with Reina Silva and Ari Fournier. He and Ari started dating in July 2021.